Clinical Proof

 

Neova

Clinical Proof: Real Science. Proven Results.

Clinical research has demonstrated that copper and DNA repair play fundamental roles in skin health. By prompting the skin’s ability to self-correct, copper is a powerful collagen and elastin promoter and plays an antioxidative role in the body, increasing the benefits of natural tissue building processes. The role of DNA repair enzymes for intense reparation and protection has been documented in multiple clinical studies, proving that the consequences of UV-induced damage can be significantly reduced.

References:
  1. Linder MC. Biochemistry of Copper. E. Freiden, Ed. Plenum Press. 1991.
  2. Schlesinger DH, et al. Growth-modulating serum tripeptide glycyl-histidyl-lysine. Experientia 33: 324. 1977.
  3. Fish, et al. Evaluation of glycyl-L-histidyl-L-lysine copper complex in acute wound healing. Effects in post Mohs' surgery wounds. Wounds 3: 171. 1991.
  4. Mulder, et al. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl-L-histidyl-L-lysine copper. Wound Rep and Regen 2: 259. 1994.
  5. Maquart, et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(II) in rat experimental wounds. J Clin Invest 92: 2368. 1993.
  6. Schmidt, et al. The combined effects of glycyl-L-histidyl-L-lysine:copper (II) and cell tak on the healing of linear incision wounds. Wounds 6: 62. 1994.
  7. Raju, et al. Ceruloplasmin, copper ions, and angiogenesis. J Nat Cancer Inst 69. 1982.
  8. Miller, et al. Effects of glycyl-histidyl-lysyl chelated Cu (II) on ferritin dependent lipid peroxidation. Antioxidants in Therapy and Preventative Medicine. Plenum Pub Corp. 1990.
  9. Trachy, et al. Phototrichogram analysis of hair follicle stimulation: a pilot clinical study with a peptide-copper complex. Dermatologic Research Techniques. H. Maibach, Ed. CRC Press. 1996.
  10. Vogt, et al. Dry, moist, and wet skin wound repair. Ann Plas Surg 34 (5). 1995.
  11. Data on file ProCyte Corporation.
  12. Oddos T; Jumeau-Lafond A; Ries G. 2002 Feb 22-27. Requirement Of Copper And Tripeptide Glycyl-L-Histidyl-L-Lysine-Cu (GHK) Complex Formation For Collagen Synthesis Activity In Normal Human Dermal Fibroblasts. Presented at the American Academy of Dermatology 60th Annual Meeting. New Orleans, LA.